Search results for "Primary and secondary immunity"

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Molecular mechanisms of primary and secondary mucosal immunity using avian infectious bronchitis virus as a model system

2007

Although mucosal immune responses are critical for protection of hosts from clinical illness and even mortality caused by mucosal pathogens, the molecular mechanism of mucosal immunity, which is independent of systemic immunity, remains elusive. To explore the mechanistic basis of mucosal protective immunity, gene transcriptional profiling in mucosal tissues was evaluated after the primary and secondary immunization of animals with an attenuated avian infectious bronchitis virus (IBV), a prototype of Coronavirus and a well-characterized mucosal pathogen. Results showed that a number of innate immune factors including toll-like receptors (TLRs), retinoic-acid-inducible gene-1 (RIG-1), type I…

animal diseasesRespiratory Tract DiseasesLymphocyte Activationmedicine.disease_causeDC dendritic cellMucosal immunityCXCR chemokine (C-X-C motif) receptorCCR chemokine (C-C motif) receptorOligonucleotide Array Sequence AnalysisCoronavirusbiologyReverse Transcriptase Polymerase Chain ReactionAcquired immune systemSpecific Pathogen-Free OrganismsCytokinesAntibodyAvian infectious bronchitis virusCoronavirus InfectionsIBV infectious bronchitis virusInfectious bronchitis virusImmunologychemical and pharmacologic phenomenaArticlePrimary and secondary immunityMolecular mechanismIBVTranscriptional regulationImmune systemImmunitymedicineAnimalsIFN interferonTLR toll-like receptorImmunity MucosalPoultry DiseasesInnate immune systemGeneral VeterinaryGene Expression ProfilingComplement System ProteinsTh1 Cellsbiochemical phenomena metabolism and nutritionCTL cytotoxic T lymphocytebiology.organism_classificationIg immunoglobulinIL interleukinMucosal immunologyImmunologybiology.proteinRNAbacteriaImmunizationChickensVeterinary Immunology and Immunopathology
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